Heterogeneity of multiple sclerosis pathogenesis: Implications for diagnosis and therapy

Hans Lassmann, Wolfgang Brück, Claudia Lucchinetti

Research output: Contribution to journalReview articlepeer-review

508 Scopus citations


Multiple sclerosis is a chronic inflammatory disease of the nervous system in which a T-cell-mediated inflammatory process is associated with destruction of myelin sheaths. Although demyelination is the primary event, axons are also destroyed in the lesions, and the loss of axons correlates with permanent functional deficit. Here, we discuss evidence that demyelination and axonal destruction follow different pathogenetic pathways in subgroups of patients. This might, at least in part, explain the heterogeneity in genetic susceptibility, clinical presentation and response to treatment observed between individuals.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalTrends in Molecular Medicine
Issue number3
StatePublished - 2001

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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