TY - JOUR
T1 - Heterogeneity of multiple sclerosis pathogenesis
T2 - Implications for diagnosis and therapy
AU - Lassmann, Hans
AU - Brück, Wolfgang
AU - Lucchinetti, Claudia
N1 - Funding Information:
These projects were funded by grants of the Bundesministerium für Bildung, Wissenschaft und Kunst (GZ 70.056/2-Pr/4/99), the Gemeinnützige Hertie Stiftung (GHS 2/540/99) and the US Multiple Sclerosis Society (RG 3051-A-1).
PY - 2001
Y1 - 2001
N2 - Multiple sclerosis is a chronic inflammatory disease of the nervous system in which a T-cell-mediated inflammatory process is associated with destruction of myelin sheaths. Although demyelination is the primary event, axons are also destroyed in the lesions, and the loss of axons correlates with permanent functional deficit. Here, we discuss evidence that demyelination and axonal destruction follow different pathogenetic pathways in subgroups of patients. This might, at least in part, explain the heterogeneity in genetic susceptibility, clinical presentation and response to treatment observed between individuals.
AB - Multiple sclerosis is a chronic inflammatory disease of the nervous system in which a T-cell-mediated inflammatory process is associated with destruction of myelin sheaths. Although demyelination is the primary event, axons are also destroyed in the lesions, and the loss of axons correlates with permanent functional deficit. Here, we discuss evidence that demyelination and axonal destruction follow different pathogenetic pathways in subgroups of patients. This might, at least in part, explain the heterogeneity in genetic susceptibility, clinical presentation and response to treatment observed between individuals.
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U2 - 10.1016/S1471-4914(00)01909-2
DO - 10.1016/S1471-4914(00)01909-2
M3 - Review article
C2 - 11286782
AN - SCOPUS:0035096330
SN - 1471-4914
VL - 7
SP - 115
EP - 121
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 3
ER -