@article{2be7104f17aa49b4a4af0323900d9c79,
title = "Heritability of dietary traits that contribute to nephrolithiasis in a cohort of adult sibships",
abstract = "Background: Kidney stones and their risk factors aggregate in families, yet few studies have estimated the heritability of known risk factors. Objective: Estimate the heritability of dietary risk factors for kidney stones. Methods: Dietary intakes were assessed using the Viocare Food Frequency Questionnaire in sibships enrolled in the Rochester, MN cohort of the Genetic Epidemiology Network of Arteriopathy. Measures of urinary supersaturation were determined using 24 h urine samples. Heritabilities and genetic correlations were estimated using variance components methods. Results: Samples were available from 620 individuals (262 men, 358 women, mean (SD) age 65 (9) years). Dietary intakes of protein, sucrose, and calcium had strong evidence for heritability (p < 0.01) after adjustment for age, sex, height and weight. Among the significantly heritable dietary intakes (p < 0.05), genetic factors explained 22–50 % of the inter-individual variation. Significant genetic correlations were observed among dietary protein, dietary sucrose, and dietary calcium intakes (p < 0.001). Conclusions: Evidence from this relatively large cohort suggests a strong heritable component to dietary intakes of protein, sucrose and calcium that contributes to nephrolithiasis risk. Further efforts to understand the interplay of genetic and environmental risk factors in kidney stone pathogenesis are warranted.",
keywords = "Diet, Heritability, Nephrolithiasis, Supersaturation",
author = "Lieske, {John C.} and Turner, {Stephen T.} and Edeh, {Samuel N.} and Ware, {Erin B.} and Kardia, {Sharon L.R.} and Smith, {Jennifer A.}",
note = "Funding Information: The Genetic Epidemiology Network of Arteriopathy (GENOA), a member of the Family Blood Pressure Program (FBPP), recruited non-Hispanic white hypertensive sibships from Rochester, Minnesota for linkage and association studies to investigate the genetic underpinnings of hypertension and target organ damage related to hypertension between 1996–2001 during Phase I []. In Phase II (2000–2004), 1241 Rochester participants were successfully re-recruited to measure potential target organ damage due to hypertension. The Genetic Determinants of Urinary Lithogenicity (GDUL) study (2006–2012) is an ancillary study of the Phase III GENOA Genetics of Chronic Kidney Disease (CKD) Study. GDUL was initially funded by a Mayo Foundation Grant and timed with a CKD visit and subsequently by a separate NIH grant R01 DK073537 (GDUL visit). All participants in the Rochester, MN GENOA cohort were invited to participate in this study which consisted of one to three study visits (CKD and GDUL), one to three 24 h urine collections, and a diet questionnaire. Having a history of kidney stones was not a criterion nor exclusion for study participation. Participants were excluded from this study if they were in endstage renal failure (stage 5 CKD). The analysis sample for this report comprised 620 participants in 387 sibships. Funding Information: This work was supported by R01 DK077950, R01 DK073537, U01 HL054457, R01 HL087660, the Mayo Clinic O{\textquoteright}Brien Urology Research Center P50 DK083007, and Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), all funded by the National Institutes of Health. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Publisher Copyright: {\textcopyright} 2015, Italian Society of Nephrology.",
year = "2016",
month = feb,
day = "1",
doi = "10.1007/s40620-015-0204-2",
language = "English (US)",
volume = "29",
pages = "45--51",
journal = "Journal of Nephrology",
issn = "1121-8428",
publisher = "Wichtig Publishing",
number = "1",
}