TY - JOUR
T1 - Hereditary pancreatic cancer
AU - Klatte, Derk C.F.
AU - Wallace, Michael B.
AU - Löhr, Matthias
AU - Bruno, Marco J.
AU - van Leerdam, Monique E.
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Pancreatic cancer is one of the deadliest malignancies. Therefore, there is an urgent need to detect pancreatic cancer in an earlier stage to improve outcomes. A variety of hereditary cancer syndromes have been associated with an increased risk of developing pancreatic cancer, and these individuals may benefit from surveillance programs. Surveillance programs have shown potential to improve outcomes, but have important risks such as overtreatment. In this review we will discuss the definitions and epidemiology of hereditary pancreatic cancer, recommendations for genetic testing and participation in surveillance. Important aspects are differences in surveillance strategies, target lesions, and potential benefits and harms of surveillance. Lastly we will highlight future directions for research and improvement of care for individuals at high-risk of pancreatic cancer.
AB - Pancreatic cancer is one of the deadliest malignancies. Therefore, there is an urgent need to detect pancreatic cancer in an earlier stage to improve outcomes. A variety of hereditary cancer syndromes have been associated with an increased risk of developing pancreatic cancer, and these individuals may benefit from surveillance programs. Surveillance programs have shown potential to improve outcomes, but have important risks such as overtreatment. In this review we will discuss the definitions and epidemiology of hereditary pancreatic cancer, recommendations for genetic testing and participation in surveillance. Important aspects are differences in surveillance strategies, target lesions, and potential benefits and harms of surveillance. Lastly we will highlight future directions for research and improvement of care for individuals at high-risk of pancreatic cancer.
KW - Familial pancreatic cancer
KW - Hereditary pancreatic cancer
KW - High-risk individuals
KW - Pancreatic ductal adenocarcinoma
KW - Surveillance
UR - http://www.scopus.com/inward/record.url?scp=85122234046&partnerID=8YFLogxK
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U2 - 10.1016/j.bpg.2021.101783
DO - 10.1016/j.bpg.2021.101783
M3 - Review article
C2 - 35988957
AN - SCOPUS:85122234046
SN - 1521-6918
VL - 58-59
JO - Best Practice and Research: Clinical Gastroenterology
JF - Best Practice and Research: Clinical Gastroenterology
M1 - 101783
ER -