Hereditary nonpolyposis colorectal cancer and colonic adenomas: Aggressive adenomas?

Henry T. Lynch, Thomas Smyrk, Jeremy R. Jass

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Hereditary nonpolyposis colorectal cancer (HNPCC) results from an inherited defect in one of the genes responsible for repair of errors that occur during DNA replication. Affected individuals have high risk for cancers of the colon and certain extracolonic sites. It appears that HNPCC patients form adenomas at about the same rate as the general population and there is circumstantial evidence that adenoma is the precursor to colorectal carcinoma in the syndrome. It is hypothesized that HNPCC features accelerated progression from colonie adenoma to carcinoma, a process theoretically driven by the inability to repair DNA mismatches. Evidence in support of the “Aggressive Adenoma” in HNPCC is provided. We discuss our recommendations for colono‐scopic surveillance on an annual basis for HNPCC gene‐positive individuals, and for genetic counseling. © 1995 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)406-410
Number of pages5
JournalSeminars in Surgical Oncology
Issue number6
StatePublished - Jan 1 1995


  • accelerated progression to cancer
  • colonie adenomas
  • hereditary nonpolyposis colorectal cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology


Dive into the research topics of 'Hereditary nonpolyposis colorectal cancer and colonic adenomas: Aggressive adenomas?'. Together they form a unique fingerprint.

Cite this