Hereditary nonpolyposis colorectal cancer

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant colon cancer syndrome. The first description of a cancer-prone family with HNPCC dates back to the late 1800s.1 However, it was not until the work of Lynch in the 1970s that a more complete clinical picture of this disorder began to emerge.2,3 The diagnosis of HNPCC has, until recently, been based primarily on family history. As a result, reliably differentiating patients with HNPCC from those with sporadic cancer has been difficult. However, the constellation of several clinical characteristics, in addition to family history, may raise suspicion of HNPCC.

Original languageEnglish (US)
Title of host publicationMolecular Pathology in Clinical Practice
PublisherSpringer New York
Number of pages10
ISBN (Print)038733226X, 9780387332260
StatePublished - 2007

ASJC Scopus subject areas

  • General Medicine


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