Hereditary and Common Familial Colorectal Cancer: Evidence for Colorectal Screening

N. Jewel Samadder, Kory Jasperson, Randall W. Burt

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6 % of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30 % of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines.

Original languageEnglish (US)
Pages (from-to)734-747
Number of pages14
JournalDigestive diseases and sciences
Issue number3
StatePublished - Mar 1 2015


  • Colorectal cancer
  • FAP
  • Familial
  • Hereditary
  • Lynch
  • Screening

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


Dive into the research topics of 'Hereditary and Common Familial Colorectal Cancer: Evidence for Colorectal Screening'. Together they form a unique fingerprint.

Cite this