Hepatopulmonary syndrome - A liver-induced lung vascular disorder

Roberto Rodríguez-Roisin, Michael J. Krowka

Research output: Contribution to journalReview articlepeer-review

417 Scopus citations


The hepatopulmonary syndrome is characterized by defects in oxygenation due to pulmonary abnormalities associated with chronic liver disease. Dyspnea and hypoxemia can be severe and often worsen in the upright position. Gross dilatation of the precapillary and capillary vessels occurs with ventilation-perfusion mismatch. The syndrome usually improves after liver transplantation.

Original languageEnglish (US)
Pages (from-to)2378
Number of pages1
JournalNew England Journal of Medicine
Issue number22
StatePublished - May 29 2008

ASJC Scopus subject areas

  • General Medicine


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