Hepatocyte liver-assist systems - A clinical update

Scott L. Nyberg, Sri Prakash Misra

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


Liver failure is a serious problem that affects thousands of people in the United States each year. Other than liver transplantation, a supportive therapy has been unavailable for patients with liver failure that is refractory to medical treatment. An apparent solution to this problem is a hepatocyte liver-assist system. Such a system is composed of mammalian hepatocytes loaded in a mechanical apparatus, such as a hollow fiber cartridge. During extracorporeal perfusion of the system, the hepatocytes provide metabolic function to the patient with liver failure. At least two extracorporeal hepatocyte systems have shown promise in human clinical trials of acute liver failure. In fact, one system has gained approval from the Food and Drug Administration for testing in a randomized multicenter clinical trial. In this article, key issues of clinical testing are reviewed, and major contributions and questions that remain unresolved are emphasized.

Original languageEnglish (US)
Pages (from-to)765-771
Number of pages7
JournalMayo Clinic proceedings
Issue number8
StatePublished - 1998

ASJC Scopus subject areas

  • General Medicine


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