Hepatic spiral CT: Reduction of dose of intravenous contrast material

James A. Brink, Jay P. Heiken, Howard P. Forman, Stuart S. Sagel, Paul L. Molina, Paul C. Brown

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


PURPOSE: To assess the potential for reduction of contrast material dose in hepatic spiral computed tomography (CT). MATERIALS AND METHODS: Four hundred eighty-seven outpatients were randomized prospectively into nine biphasic and eight uniphasic injection protocols: 75, 100, or 125 mL of 240, 300, or 350 mg of iodine per milliliter of iohexol (18-44 grams of iodine). Protocols were compared according to the maximum hepatic enhancement (MAX) and the contrast enhancement index (CEI). RESULTS: Uniphasic injection was superior to biphasic injection for all protocols. No statistically significant difference in contrast enhancement was present for 38-44 grams of iodine with the uniphasic technique. Adequate enhancement thresholds (MAX > 50 HU, CEI at 30 HU > 300 HU x sec) were exceeded in more than 70% of heavy patients (>183 lb [83 kg]) with uniphasic injection of 38 g. For thin patients (<183 lb [83 kg]), uniphasic injection of 26 g produced adequate enhancement. CONCLUSION: Contrast material dose may be reduced by up to 40% in thin patients undergoing hepatic spiral CT after uniphasic injection of contrast material; this may result in substantial cost savings.

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
Issue number1
StatePublished - Oct 1995


  • Computed tomography (CT), contrast media
  • Computed tomography (CT), helical
  • Iohexol
  • Liver, CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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