Hepatic soluble epoxide hydrolase: A promising target for unveiling the liver-brain axis in Alzheimer's disease

Yasuteru Inoue; Michael Bamkole; Takahisa Kanekiyo

doi:10.1016/j.neuron.2023.08.019

Hepatic soluble epoxide hydrolase: A promising target for unveiling the liver-brain axis in Alzheimer's disease

Yasuteru Inoue, Michael Bamkole, Takahisa Kanekiyo

Neuroscience

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Wu and Dong et al.¹ report that hepatic soluble epoxide hydrolase (sEH) manipulation impacts amyloid-β (Aβ) deposits and cognitive impairment in mouse models for Alzheimer's disease (AD), suggesting that hepatic sEH activity is a promising therapeutic target to treat AD.

Original language	English (US)
Pages (from-to)	2775-2777
Number of pages	3
Journal	Neuron
Volume	111
Issue number	18
DOIs	https://doi.org/10.1016/j.neuron.2023.08.019
State	Published - Sep 20 2023

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2023.08.019

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title = "Hepatic soluble epoxide hydrolase: A promising target for unveiling the liver-brain axis in Alzheimer's disease",

abstract = "Wu and Dong et al.1 report that hepatic soluble epoxide hydrolase (sEH) manipulation impacts amyloid-β (Aβ) deposits and cognitive impairment in mouse models for Alzheimer's disease (AD), suggesting that hepatic sEH activity is a promising therapeutic target to treat AD.",

author = "Yasuteru Inoue and Michael Bamkole and Takahisa Kanekiyo",

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AU - Inoue, Yasuteru

AU - Bamkole, Michael

AU - Kanekiyo, Takahisa

PY - 2023/9/20

Y1 - 2023/9/20

N2 - Wu and Dong et al.1 report that hepatic soluble epoxide hydrolase (sEH) manipulation impacts amyloid-β (Aβ) deposits and cognitive impairment in mouse models for Alzheimer's disease (AD), suggesting that hepatic sEH activity is a promising therapeutic target to treat AD.

AB - Wu and Dong et al.1 report that hepatic soluble epoxide hydrolase (sEH) manipulation impacts amyloid-β (Aβ) deposits and cognitive impairment in mouse models for Alzheimer's disease (AD), suggesting that hepatic sEH activity is a promising therapeutic target to treat AD.

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DO - 10.1016/j.neuron.2023.08.019

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Hepatic soluble epoxide hydrolase: A promising target for unveiling the liver-brain axis in Alzheimer's disease

Abstract

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