Hemoptysis in Proteus syndrome

Craig E. Daniels, David J. Driscoll, Eric S. Edell, Mark E. Wylam

Research output: Contribution to journalReview articlepeer-review


We report a patient with Proteus syndrome who presented with massive hemoptysis. Proteus syndrome is a rare congenital disorder characterized by overgrowth of tissues, including skin, vasculature, and skeleton. The asymmetric overgrowth of these tissues result in marked deformity and subsequent medical complications known to include deep venous thrombosis and subsequent pulmonary embolism. Although vascular malformations of visceral organs have been previously reported in Proteus syndrome, endobronchial involvement resulting in massive hemoptysis, as reported here, represents a novel finding. This complication is the result of bronchial neovascularization caused by Proteus syndrome and not pulmonary embolism. We discuss these findings and review the literature regarding pulmonary complications of Proteus syndrome.

Original languageEnglish (US)
Pages (from-to)171-173
Number of pages3
JournalJournal of Bronchology
Issue number3
StatePublished - Jul 2005


  • Hemoptysis
  • Proteus syndrome
  • Pulmonary embolus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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