Hemophagocytic Lymphohistiocytosis for the Internist and Other Primary Care Providers

Tanmayi Srinivas Pai, Fernando F. Stancampiano, Candido Rivera

Research output: Contribution to journalReview articlepeer-review


Hemophagocytic lymphohistiocytosis (HLH) syndrome is a hyperinflammatory state that leads to life-threatening, disproportionate activation of the immune system and may be confused for and concomitantly exist with sepsis. However, its treatment differs from sepsis, requiring early initiation of immunosuppressive treatment. While HLH syndrome is more commonly diagnosed in children, internists and other primary care providers must be familiar with the diagnosis and treatment of adult patients with HLH in the hospital and outpatient setting. In this article, we review the essentials that an internist and other primary care providers managing adult HLH patients should know.

Original languageEnglish (US)
JournalJournal of Primary Care and Community Health
StatePublished - 2021


  • HLH
  • hemophagocytic lymphohistiocytosis
  • primary care

ASJC Scopus subject areas

  • Community and Home Care
  • Public Health, Environmental and Occupational Health


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