Hemolytic anemia with serum and erythrocyte-bound low-molecular-weight IgM

Neil Elliot Kay, Steven D. Douglas, James J. Mond, Jeffrey S. Flier, Shaul Kochwa, Richard E. Rosenfield

Research output: Contribution to journalArticlepeer-review


A 49-yr-old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular-weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low-molecular-weight IgM. The IgM fraction of the patient's serum contained anti-I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low-molecular-weight IgM possibly related to hemolysis in addition to 19S IgM anti-I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.

Original languageEnglish (US)
Pages (from-to)216-225
Number of pages10
JournalClinical Immunology and Immunopathology
Issue number2
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine


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