TY - JOUR
T1 - Hemoglobin concentration and aerobic work capacity in women following induced erythrocythemia
AU - Robertson, R. J.
AU - Gilcher, R.
AU - Metz, K. F.
AU - Caspersen, C. J.
AU - Allison, T. G.
AU - Abbott, R. A.
AU - Skrinar, G. S.
AU - Krause, J. R.
AU - Nixon, P. A.
PY - 1984
Y1 - 1984
N2 - The effect of induced erythrocythemia on hemoglobin concentration ([Hb]) and aerobic work capacity was determined for nine women. Cycle tests were performed at prereinfusion (T1), 2 days after a placebo infusion (T2), 2 days postreinfusion of 334 ml of red blood cells (T3), 8 days postreinfusion (T4), and 14 days postreinfusion (T5). T1 and T2 responses did not differ, negating a placebo effect. [Hb] increased from 12.7 g·dl at T1 to 14.7 g·dl at T3 and then remained constant at T4 and T5. Hematocrit increased from 38.1% at T1 to 44.9% at T3 and then remained constant at T4 and T5. Submaximal O2 uptake (Vo2) and stroke volume (SV) did not change from T1 through T5. Submaximal cardiac output (Q) and heart rate (HR) decreased from T1 to T3 and then remained constant at T4 and T5. Arteriovenous O2 difference increased from T1 to T3 and then remained constant at T4 and T5. Maximal Vo2 was greater at T3 (2.65 l·min-1), T4 (2.66 l·min-1), and T5 (10,380 kg·m) than at T1 (8,747 kg·m). Maximal values for Q, HR, and SV were unchanged from T1 through T5. At maximum, arteriovenous O2 difference and Hb flow rate increased from T1 to T3 and then remained constant at T4 and T5. The greater postreinfusion [Hb] improved O2 transport capacity and appeared to regulate circulatory responses.
AB - The effect of induced erythrocythemia on hemoglobin concentration ([Hb]) and aerobic work capacity was determined for nine women. Cycle tests were performed at prereinfusion (T1), 2 days after a placebo infusion (T2), 2 days postreinfusion of 334 ml of red blood cells (T3), 8 days postreinfusion (T4), and 14 days postreinfusion (T5). T1 and T2 responses did not differ, negating a placebo effect. [Hb] increased from 12.7 g·dl at T1 to 14.7 g·dl at T3 and then remained constant at T4 and T5. Hematocrit increased from 38.1% at T1 to 44.9% at T3 and then remained constant at T4 and T5. Submaximal O2 uptake (Vo2) and stroke volume (SV) did not change from T1 through T5. Submaximal cardiac output (Q) and heart rate (HR) decreased from T1 to T3 and then remained constant at T4 and T5. Arteriovenous O2 difference increased from T1 to T3 and then remained constant at T4 and T5. Maximal Vo2 was greater at T3 (2.65 l·min-1), T4 (2.66 l·min-1), and T5 (10,380 kg·m) than at T1 (8,747 kg·m). Maximal values for Q, HR, and SV were unchanged from T1 through T5. At maximum, arteriovenous O2 difference and Hb flow rate increased from T1 to T3 and then remained constant at T4 and T5. The greater postreinfusion [Hb] improved O2 transport capacity and appeared to regulate circulatory responses.
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U2 - 10.1152/jappl.1984.57.2.568
DO - 10.1152/jappl.1984.57.2.568
M3 - Article
C2 - 6469823
AN - SCOPUS:0021232358
SN - 0161-7567
VL - 57
SP - 568
EP - 575
JO - Journal of Applied Physiology Respiratory Environmental and Exercise Physiology
JF - Journal of Applied Physiology Respiratory Environmental and Exercise Physiology
IS - 2
ER -