Hemodynamics rounds: Hemodynamics of mitral valve interventions

James W. Lloyd, Charanjit S. Rihal, Mackram F. Eleid

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Mitral valvulopathy presents as regurgitation, stenosis, or mixed disease and can occur in both native and prosthetic valves. Such disease develops in conjunction with pathophysiologic changes in the left atrium (LA) and drives changes in LA compliance, pressure, and thus clinical syndromes. With advances in the understanding and treatment of structural heart disease and in the setting of higher-risk patient populations, less-invasive transcatheter approaches have become increasingly commonplace in the treatment of mitral valve disease. Over time, transcatheter mitral valve interventions have evolved to include paravalvular leak closure, mitral valve repair, and mitral valve replacement. Parallel to this evolution, advances in invasive intracardiac pressure monitoring, particularly at the level of the LA, have also occurred. These advances emphasize the unique interplay between mitral valve disease and LA function; account for limitations of noninvasive assessment; and guide beneficial outcomes in each area of transcatheter mitral valve intervention. As a result, continuous transseptal LA pressure monitoring has developed into an indispensable instrument in successful percutaneous mitral valve intervention, complementing traditional noninvasive assessment.

Original languageEnglish (US)
Pages (from-to)712-724
Number of pages13
JournalCatheterization and Cardiovascular Interventions
Issue number3
StatePublished - Sep 1 2020


  • atrial
  • hemodynamic
  • invasive
  • mitral
  • pressure
  • transcatheter

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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