Heme-oxygenase-2 immunolabelling in pig jejunum

Nilce Mitiko Matsuda, Steven M. Miller, Joseph H. Szurszewski

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Heme-oxygenase-2 generates carbon monoxide in the enteric nervous system and in interstitial cells of Cajal in the canine, mouse and human jejunum. Carbon monoxide is considered a non-adrenergic and non-cholinergic inhibitory neurotransmitter and it establishes and maintains the resting membrane potential in the stomach and small intestine. The aim of this study was to determine the distribution of heme-oxygenase-2 in the enteric nervous system of the pig jejunum. Heme-oxygenase-2 immunoreactivity was found in neurons of myenteric ganglia and in nerve fibers in the circular and longitudinal muscle layers. These results suggest that carbon monoxide is produced in the enteric nervous system of the pig jejunum and might mediate inhibitory neural activity in myenteric ganglia and inhibitory neural input to smooth muscle cells in the circular and longitudinal muscle layers.

Original languageEnglish (US)
Pages (from-to)402-406
Number of pages5
JournalActa Histochemica
Issue number4
StatePublished - Jul 2010


  • Enteric nervous system
  • Heme-oxygenase-2
  • Non-adrenergic and non-cholinergic
  • Pig jejunum
  • Smooth muscle

ASJC Scopus subject areas

  • Histology
  • Cell Biology


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