Hematologic Malignancies Identified in Patients with Hypereosinophilia and Hypereosinophilic Syndromes

Jay J. Jin, Joseph H. Butterfield, Catherine R. Weiler

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background: Certain hematologic malignancies are associated with hypereosinophilia or tissue eosinophilia. It is unclear if patients with hypereosinophilia are more likely to develop one of these malignancies. Objective: This study sought to quantify the specific hematologic malignancies that developed in patients with preexisting hypereosinophilia. Methods: Adult patients with eosinophilia associated with the development of hematologic malignancy were identified by a retrospective review of the Mayo Clinic patient database between 2000 and 2013. Results: Of 2642 patients identified with eosinophilia, hypereosinophilia, or hypereosinophilic syndrome, 25 (aged 28.8 to 86.1 years; 13 male; 12 female) had a diagnosis of either lymphoma or leukemia. The majority of these patients had non-Hodgkin lymphoma (17 of 25). T-cell-derived lymphomas were more common (12 of 17) than B-cell-derived lymphomas (4 of 17). In patients with leukemia (8 of 25), chronic lymphocytic leukemia (4 of 8) was most common, followed by chronic eosinophilic leukemia (3 of 8). Approximately 5.1% of patients with hypereosinophilia developed a hematologic malignancy. On average, the malignancy developed 30.0 ± 42.7 months after the onset of hypereosinophilia. Conclusions: The development of hematologic malignancies in this referral population with eosinophilia was rare (0.2%), but more common in those with hypereosinophilia (5.1%). Non-Hodgkin's lymphomas, particularly T-cell-derived malignancies, were most commonly diagnosed. Patients with preexisting hypereosinophilia were diagnosed with hematologic conditions that were rarer within the general population.

Original languageEnglish (US)
Pages (from-to)920-925
Number of pages6
JournalJournal of Allergy and Clinical Immunology: In Practice
Issue number6
StatePublished - Nov 2015


  • Hematologic malignancy
  • Hypereosinophilia
  • Hypereosinophilic syndrome
  • Leukemia
  • Lymphoma

ASJC Scopus subject areas

  • Immunology and Allergy


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