Hematologic investigations: Morphologic and phenotypic features of myeloma marrow diagnosis

Thomas M. Grogan, Deborah Gelbspan, Lisa Rimsza

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


This chapter emphasizes both the morphologic and phenotypic features of the bone marrow in plasma cell myeloma. It details the morphologic features of both trephine biopsies and marrow aspirations. It emphasizes the salient phenotypic features of marrow myeloma cells, in contrast with normal plasma cells. The myeloma cell phenotype is discussed from the perspective of both tissue section immunohistochemistry (IHC) and flow cytometry (FACS analysis). The specific criteria for myeloma diagnosis are discussed and illustrated in Figs 8.1-8.21. Finally, the differential diagnosis of myeloma is discussed emphasizing the key morphologic and phenotypic diagnostic criteria of each entity.

Original languageEnglish (US)
Title of host publicationMultiple Myeloma and Related Disorders
PublisherCRC Press
Number of pages23
ISBN (Electronic)9781444114140
ISBN (Print)9780340810101
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • General Medicine


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