Hemangiopericytoma of the central nervous system: A review of 94 cases

Hernando Mena, Jorge L. Ribas, Gholam H. Pezeshkpour, David N. Cowan, Joseph E. Parisi

Research output: Contribution to journalReview articlepeer-review

238 Scopus citations


Ninety-four cases of central nervous system hemangiopericytoma (CNS-HPC) are reported. Hemangiopericytoma was found more commonly in men than in women. The mean age at diagnosis was 40.9 years for men and 47 years for women. The tumor was found throughout the entire CNS, usually superficially and closely related to the meninges. Based on multiple histologic variables, the original tumors were divided into differentiated ( = 67) and anaplastic (n = 27). Anaplastic HPC was characterized by the presence of necrosis and/or greater than five mitoses per ten 400× microscopic fields, and at least two of the following microscopic features: hemorrhage, moderate to high nuclear atypia, and moderate to high cellularity. For those patients known to be dead, median survival time was 144 months for differentiated HPC and 62 months for anaplastic HPC. Fiftyseven (60.6%) patients had one or more recurrences and metastasis developed in 22 (23.4%). Thirty-five of 56 patients with differentiated HPC had recurrence, while 22 of 26 patients with anaplastic HPC had recurrence. Bone, liver, lung, central nervous system, and abdominal cavity were the most common sites of metastasis. Postoperative radiotherapy and/or chemotherapy were significantly associated with increased patient survival time.

Original languageEnglish (US)
Pages (from-to)84-91
Number of pages8
JournalHuman Pathology
Issue number1
StatePublished - Jan 1991


  • angioblastic meningioma
  • central nervous system
  • hemangiopericytic meningioma
  • hemangiopericytoma
  • neoplasm

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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