Heart transplantation: Mechanisms of donor heart failure

O. E. Pajaro, D. Nyhan

Research output: Contribution to journalReview articlepeer-review


After a brief overview of the current status of heart transplantation, this chapter describes the molecular mechanisms underlying heart failure, mechanistic aspects of donor organ dysfunction, and the implications of an anoxic ischemic insult (an inherent part of harvesting and implantation). Although the understanding of these mechanisms may not result in a change in our current practice, it is likely that the characterization of specific mechanistic perturbations in donor organs will allow for the development of targeted interventions.

Original languageEnglish (US)
Pages (from-to)181-190
Number of pages10
JournalProblems in Anesthesia
Issue number2
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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