Heart Failure With Preserved Ejection Fraction: JACC Scientific Statement

Barry A. Borlaug, Kavita Sharma, Sanjiv J. Shah, Jennifer E. Ho

Research output: Contribution to journalReview articlepeer-review


The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF) continue to rise in tandem with the increasing age and burdens of obesity, sedentariness, and cardiometabolic disorders. Despite recent advances in the understanding of its pathophysiological effects on the heart, lungs, and extracardiac tissues, and introduction of new, easily implemented approaches to diagnosis, HFpEF remains under-recognized in everyday practice. This under-recognition presents an even greater concern given the recent identification of highly effective pharmacologic-based and lifestyle-based treatments that can improve clinical status and reduce morbidity and mortality. HFpEF is a heterogenous syndrome and recent studies have suggested an important role for careful, pathophysiological-based phenotyping to improve patient characterization and to better individualize treatment. In this JACC Scientific Statement, we provide an in-depth and updated examination of the epidemiology, pathophysiology, diagnosis, and treatment of HFpEF.

Original languageEnglish (US)
Pages (from-to)1810-1834
Number of pages25
JournalJournal of the American College of Cardiology
Issue number18
StatePublished - May 9 2023


  • diagnosis
  • epidemiology
  • heart failure with preserved ejection fraction
  • pathophysiology
  • treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Heart Failure With Preserved Ejection Fraction: JACC Scientific Statement'. Together they form a unique fingerprint.

Cite this