Heart Failure with Preserved Ejection Fraction in Perspective

Marc A. Pfeffer, Amil M. Shah, Barry A. Borlaug

Research output: Contribution to journalReview articlepeer-review

130 Scopus citations


Approximately half of the patients with signs and symptoms of heart failure have a left ventricular ejection fraction that is not markedly abnormal. Despite the historically initial surprise, heightened risks for heart failure specific major adverse events occur across the broad range of ejection fraction, including normal. The recognition of the magnitude of the problem of heart failure with preserved ejection fraction in the past 20 years has spurred an explosion of clinical investigation and growing intensity of informative outcome trials. This article addresses the historic development of this component of the heart failure syndrome, including the epidemiology, pathophysiology, and existing and planned therapeutic studies. Looking forward, more specific phenotyping and even genotyping of subpopulations should lead to improvements in outcomes from future trials.

Original languageEnglish (US)
Pages (from-to)1598-1617
Number of pages20
JournalCirculation research
Issue number11
StatePublished - May 24 2019


  • clinical trials, phase III
  • epidemiology
  • heart failure
  • heart failure, diastolic

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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