Head and neck neoplasms: Magnetization transfer analysis

David M. Yousem, Kathleen T. Montone, Lisa M. Sheppard, Vijay M. Rao, Gregory S. Weinstein, Richard E. Hayden

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


PURPOSE: Magnetization transfer (MT) imaging enables analysis of the contribution of restricted motion protons in the macromolecular pool to magnetic resonance (MR) signal intensity. The authors undertook this study to determine whether MT ratios (MTRs) could be used to predict pathologic characteristics of head and neck neoplasms. MATERIALS AND METHODS: Fifty- four patients with pathologically proved neoplasms (squamous cell carcinomas, n = 33; non-squamous cell carcinomas, n = 11; benign masses, n = 10) underwent MT imaging. MTRs were correlated with pathologic findings. RESULTS: No statistically significant correlations were noted between MTRs and degree of differentiation, keratinization, cells per high-power field, and rate of mitosis. Statistically significant differences were found between MTRs of malignancies and muscle (P < .01), cerebrospinal fluid (P < .001), fat (P < .001), and benign neoplasms (P < .001). MTRs of muscle were higher than those of benign, squamous cell, and non-squamous cell neoplasms. CONCLUSION: MT imaging shows promise in differentiation of benign from malignant head and neck neoplasms. No statistically significant differences in MTRs were noted among malignancies.

Original languageEnglish (US)
Pages (from-to)703-707
Number of pages5
Issue number3
StatePublished - Sep 1994


  • Head and neck neoplasms, MR
  • Head and neck neoplasms, diagnosis
  • Magnetic resonance (MR), magnetization transfer contrast

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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