Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project

Martina Bocchetta, Marina Boccardi, Rossana Ganzola, Liana G. Apostolova, Gregory Preboske, Dominik Wolf, Clarissa Ferrari, Patrizio Pasqualetti, Nicolas Robitaille, Simon Duchesne, Clifford R. Jack, Giovanni B. Frisoni, George Bartzokis, Charles Decarli, Leyla Detoledo-Morrell, Andreas Fellgiebel, Michael Firbank, Lotte Gerritsen, Wouter Henneman, Ronald J. KillianyNikolai Malykhin, Jens C. Pruessner, Hilkka Soininen, Lei Wang

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Background: A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation. Methods: Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 Tand 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes. Results: Two hundred labels have been provided for the 20 magnetic resonance images. Intra- And interrater ICCs were .0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76). Conclusion: Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.

Original languageEnglish (US)
Pages (from-to)151-160.e5
JournalAlzheimer's and Dementia
Issue number2
StatePublished - 2015


  • ADNI
  • Alzheimer's disease
  • Anatomic landmark
  • Harmonization
  • Harmonized protocol
  • Hippocampal atrophy
  • Hippocampal volume
  • Hippocampus
  • MRI
  • Manual tracing
  • Medial temporal lobes
  • Neuroimaging
  • Standard operating procedures

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Health Policy
  • Developmental Neuroscience
  • Epidemiology


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