Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5-fluorouracil toxicity

Seid Hamzic, Dominic Schärer, Steven M. Offer, Didier Meulendijks, Christos Nakas, Robert B. Diasio, Stefano Fontana, Marc Wehrli, Stefan Schürch, Ursula Amstutz, Carlo R. Largiadèr

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