H-bonding mediates polarization of peptide groups in folded proteins

Nenad Juranić, Slobodan Macura, Franklyn G. Prendergast

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The carbon-nitrogen J-couplings in the hydrogen bonding chains of proteins show that H-bonding mediates peptide-group polarization, which results in the general reduction of peptide-group polarity of folded proteins in solution. The net effect is to make large regions of protein secondary structure, especially β-sheets, intrinsically more hydrophobic, contributing thereby to overall stability of the tertiary structure.

Original languageEnglish (US)
Pages (from-to)2633-2636
Number of pages4
JournalProtein Science
Issue number11
StatePublished - Nov 2003


  • NMR spin-spin coupling
  • Peptide-group polarizations
  • Protein H-bond networks

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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