H-bonding mediates polarization of peptide groups in folded proteins

Nenad Juranić; Slobodan Macura; Franklyn G. Prendergast

doi:10.1110/ps.03127103

H-bonding mediates polarization of peptide groups in folded proteins

Nenad Juranić, Slobodan Macura, Franklyn G. Prendergast

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The carbon-nitrogen J-couplings in the hydrogen bonding chains of proteins show that H-bonding mediates peptide-group polarization, which results in the general reduction of peptide-group polarity of folded proteins in solution. The net effect is to make large regions of protein secondary structure, especially β-sheets, intrinsically more hydrophobic, contributing thereby to overall stability of the tertiary structure.

Original language	English (US)
Pages (from-to)	2633-2636
Number of pages	4
Journal	Protein Science
Volume	12
Issue number	11
DOIs	https://doi.org/10.1110/ps.03127103
State	Published - Nov 2003

Keywords

NMR spin-spin coupling
Peptide-group polarizations
Protein H-bond networks

ASJC Scopus subject areas

Biochemistry
Molecular Biology

Access to Document

10.1110/ps.03127103

Cite this

@article{7597a0db3adf4ef8a34e748c58704d5b,

title = "H-bonding mediates polarization of peptide groups in folded proteins",

abstract = "The carbon-nitrogen J-couplings in the hydrogen bonding chains of proteins show that H-bonding mediates peptide-group polarization, which results in the general reduction of peptide-group polarity of folded proteins in solution. The net effect is to make large regions of protein secondary structure, especially β-sheets, intrinsically more hydrophobic, contributing thereby to overall stability of the tertiary structure.",

keywords = "NMR spin-spin coupling, Peptide-group polarizations, Protein H-bond networks",

author = "Nenad Jurani{\'c} and Slobodan Macura and Prendergast, {Franklyn G.}",

year = "2003",

month = nov,

doi = "10.1110/ps.03127103",

language = "English (US)",

volume = "12",

pages = "2633--2636",

journal = "Protein Science",

issn = "0961-8368",

publisher = "Cold Spring Harbor Laboratory Press",

number = "11",

}

TY - JOUR

T1 - H-bonding mediates polarization of peptide groups in folded proteins

AU - Juranić, Nenad

AU - Macura, Slobodan

AU - Prendergast, Franklyn G.

PY - 2003/11

Y1 - 2003/11

N2 - The carbon-nitrogen J-couplings in the hydrogen bonding chains of proteins show that H-bonding mediates peptide-group polarization, which results in the general reduction of peptide-group polarity of folded proteins in solution. The net effect is to make large regions of protein secondary structure, especially β-sheets, intrinsically more hydrophobic, contributing thereby to overall stability of the tertiary structure.

AB - The carbon-nitrogen J-couplings in the hydrogen bonding chains of proteins show that H-bonding mediates peptide-group polarization, which results in the general reduction of peptide-group polarity of folded proteins in solution. The net effect is to make large regions of protein secondary structure, especially β-sheets, intrinsically more hydrophobic, contributing thereby to overall stability of the tertiary structure.

KW - NMR spin-spin coupling

KW - Peptide-group polarizations

KW - Protein H-bond networks

UR - http://www.scopus.com/inward/record.url?scp=0142210113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142210113&partnerID=8YFLogxK

U2 - 10.1110/ps.03127103

DO - 10.1110/ps.03127103

M3 - Article

C2 - 14573874

AN - SCOPUS:0142210113

SN - 0961-8368

VL - 12

SP - 2633

EP - 2636

JO - Protein Science

JF - Protein Science

IS - 11

ER -

H-bonding mediates polarization of peptide groups in folded proteins

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this