@article{cad335faba8a470fa8da9e044d246deb,
title = "Gut and vaginal microbiomes on steroids: implications for women's health",
abstract = "This review discusses the interactions of steroids with the gut and vaginal microbiomes within each life phase of adult women and the implications for women's health. Each phase of a woman's life is characterized by distinct hormonal states which drive overall physiology of both host and commensal microbes. These host–microbiome interactions underlie disease pathology in disorders that affect women across their lifetime, including bacterial vaginosis, gestational diabetes, polycystic ovary syndrome (PCOS), anxiety, depression, and obesity. Although many associations between host health and microbiome composition are well defined, the mechanistic role of the microbiome in women's health outcomes is largely unknown. This review addresses potential mechanisms by which the microbiota influences women's health and highlights gaps in current knowledge.",
keywords = "estrogens, gut microbiome, menopause, polycystic ovary syndrome, pregnancy, progestins",
author = "Graham, {Madeline E.} and Herbert, {William G.} and Song, {Stephanie D.} and Raman, {Harshini N.} and Zhu, {Jade E.} and Gonzalez, {Paulina E.} and Walther-Ant{\'o}nio, {Marina R.S.} and Tetel, {Marc J.}",
note = "Funding Information: This work was supported, in part, by Clinical and Translational Science Award (CTSA) grant KL2 TR002379 from the National Center for Advancing Translational Science and a career enhancement award from the National Institutes of Health (NIH; grant P50 CA136393) to M.R.S.W-A. and by Wellesley College Jenkins Distinguished Chair in Neuroscience Funds (to M.J.T.). The Mayo Foundation for Medical Education and Research (inventor M.R.S.W-A.) has been issued a patent 'Methods and Materials for Treating Endometrial Cancer', US10072303B2. The content of the patent relates to the use of the microbiome to address endometrial cancer. M.R.S.W-A. is a member of the scientific advisory board of LUCA Biologics Inc. on research related to urinary tract infections, preterm birth, and reproductive medicine. The other authors declare no conflicts of interest. Funding Information: This work was supported, in part, by Clinical and Translational Science Award ( CTSA ) grant KL2 TR002379 from the National Center for Advancing Translational Science and a career enhancement award from the National Institutes of Health ( NIH ; grant P50 CA136393 ) to M.R.S.W-A., and by Wellesley College Jenkins Distinguished Chair in Neuroscience Funds (to M.J.T.). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
year = "2021",
month = aug,
doi = "10.1016/j.tem.2021.04.014",
language = "English (US)",
volume = "32",
pages = "554--565",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "8",
}