TY - JOUR
T1 - Growth patterns of fetal lung volumes in healthy fetuses and fetuses with isolated left-sided congenital diaphragmatic hernia
AU - Ruano, Rodrigo
AU - Britto, Ingrid Schwach Werneck
AU - Sananes, Nicolas
AU - Lee, Wesley
AU - Sangi-Haghpeykar, Haleh
AU - Deter, Russell L.
N1 - Publisher Copyright:
©2016 by the American Institute of Ultrasound in Medicine.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Objectives - To evaluate fetal lung growth using 3-dimensional sonography in healthy fetuses and those with congenital diaphragmatic hernia (CDH). Methods - Right and total lung volumes were serially evaluated by 3-dimensional sonography in 66 healthy fetuses and 52 fetuses with left-sided CDH between 20 and 37 weeks' menstrual age. Functions fitted to these parameters were compared for 2 groups: (1) healthy versus those with CDH; and (2) fetuses with CHD who survived versus those who died. Results - Fetal right and total lung volumes as well as fetal observed-to-expected right and total lung volume ratios were significantly lower in fetuses with CDH than healthy fetuses (P < .001) and in those fetuses with CDH who died (P < .001). The observed-to-expected right and total lung volume ratios did not vary with menstrual age in healthy fetuses or in those with CDH (independent of outcome). Conclusions - Lung volume rates were lower in fetuses with left-sided CDH compared to healthy fetuses, as well as in fetuses with CDH who died compared to those who survived. The observed-to-expected right and total lung volume ratios were relatively constant throughout menstrual age in fetuses with left-sided CDH, suggesting that the origin of their lung growth abnormalities occurred before 20 weeks and did not progress. The observed-to-expected ratios may be useful in predicting the outcome in fetuses with CDH independent of menstrual age.
AB - Objectives - To evaluate fetal lung growth using 3-dimensional sonography in healthy fetuses and those with congenital diaphragmatic hernia (CDH). Methods - Right and total lung volumes were serially evaluated by 3-dimensional sonography in 66 healthy fetuses and 52 fetuses with left-sided CDH between 20 and 37 weeks' menstrual age. Functions fitted to these parameters were compared for 2 groups: (1) healthy versus those with CDH; and (2) fetuses with CHD who survived versus those who died. Results - Fetal right and total lung volumes as well as fetal observed-to-expected right and total lung volume ratios were significantly lower in fetuses with CDH than healthy fetuses (P < .001) and in those fetuses with CDH who died (P < .001). The observed-to-expected right and total lung volume ratios did not vary with menstrual age in healthy fetuses or in those with CDH (independent of outcome). Conclusions - Lung volume rates were lower in fetuses with left-sided CDH compared to healthy fetuses, as well as in fetuses with CDH who died compared to those who survived. The observed-to-expected right and total lung volume ratios were relatively constant throughout menstrual age in fetuses with left-sided CDH, suggesting that the origin of their lung growth abnormalities occurred before 20 weeks and did not progress. The observed-to-expected ratios may be useful in predicting the outcome in fetuses with CDH independent of menstrual age.
KW - 3-Dimensional sonography
KW - Congenital diaphragmatic hernia
KW - Fetal lung
KW - Fetal lung volume
KW - Obstetric ultrasound
KW - Prenatal diagnosis
KW - Pulmonary hypoplasia
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U2 - 10.7863/ultra.15.08005
DO - 10.7863/ultra.15.08005
M3 - Article
C2 - 27091916
AN - SCOPUS:84971330163
SN - 0278-4297
VL - 35
SP - 1159
EP - 1166
JO - Journal of Ultrasound in Medicine
JF - Journal of Ultrasound in Medicine
IS - 6
ER -