@article{dfd50526ccc84071bc566407ac98249f,
title = "Greatest rapid eye movement sleep atonia loss in men and older age",
abstract = "To determine quantitative REM sleep muscle tone in men and women without REM sleep behavior disorder, we quantitatively analyzed REM sleep phasic and tonic muscle activity, phasic muscle burst duration, and automated REM atonia index in submentalis and anterior tibialis muscles in 25 men and 25 women without REM sleep behavior disorder. Men showed significantly higher anterior tibialis phasic muscle activity. Higher phasic muscle activity was independently associated with male sex and older age in multivariate analysis. Men and the elderly may be biologically predisposed to altered REM sleep muscle atonia control, and/or some may have occult neurodegenerative disease, possibly underlying the predominance of older men with REM sleep behavior disorder.",
author = "McCarter, {Stuart J.} and {St. Louis}, {Erik K.} and Boeve, {Bradley F.} and Sandness, {David J.} and Silber, {Michael H.}",
note = "Funding Information: Dr. St. Louis reports grants from Mayo Clinic CTSA, grant from Mayo Clinic Alzheimer{\textquoteright}s Diseases Research Center, during the conduct of the study; other than Inspire, Inc., outside the submitted work. Dr. Boeve reports other from Cephalon, Inc., other from Allon Pharmaceutical, grants and other from GE Healthcare, personal fees from Cambrige Medicine, personal fees from American Academy of Neurology, personal fees and other from Tau Consortium, outside the submitted work. Funding Information: The project described was supported by a Mayo Clinic Alzheimer{\textquoteright}s Disease Research Center Grant Award from the National Institute on Aging (P50 AG016574), and the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant Number 1 UL1 RR024150-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: The project described was supported by a Mayo Clinic Alzheimer{\textquoteright}s Disease Research Center Grant Award from the National Institute on Aging (P50 AG016574), and the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant Number 1 UL1 RR024150-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We also gratefully acknowledge Katie L. Hancock, Katlyn A. Arndt, Maia K. Erickson, and Grace M. Tabatabai for their assistance in quantitative analysis of muscle tone, and Lori Lynn Reinstrom in the Mayo Clinic Department of Neurology for secretarial assistance with manuscript formatting and submission. Publisher Copyright: {\textcopyright} 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.",
year = "2014",
month = sep,
doi = "10.1002/acn3.93",
language = "English (US)",
volume = "1",
pages = "733--738",
journal = "Annals of Clinical and Translational Neurology",
issn = "2328-9503",
publisher = "John Wiley and Sons Inc.",
number = "9",
}