TY - JOUR
T1 - Greater Lower Limb Fatigability in People with Prediabetes than Controls
AU - Senefeld, Jonathon W.
AU - Harmer, Alison R.
AU - Hunter, Sandra K.
N1 - Funding Information:
We thank Dr. Mehdi Maadooliat for biostatistical consultation, Bonnie Schlinder-Delap for assistance with scheduling participants, Dr. April Harkins for venipuncture and blood assays, Michael Danduran for assistance with administration and interpretation of electrocardiogram recordings during submaximal exercise testing, and Dr. Rita Deering, Dr. Joe Bartoletti, Isaac Pierre, Anna Buzzard, Courtney Linzmeier, Christine Eble, and Sarah D’Astice for assistance with data collection. We also thank the research participants for volunteering to make this study possible. This work was supported by a Marquette University Way Klingler Fellowship Award to S. K. H. and the special studies program support of the University of Sydney for A. R. H.
Publisher Copyright:
© Lippincott Williams & Wilkins.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Introduction The study purpose was to compare perceived fatigability and performance fatigability after high-velocity contractions with knee extensor muscles between people with prediabetes, people with type 2 diabetes (T2D), and controls without diabetes matched for age, body mass index, and physical activity. Methods Twenty people with prediabetes (11 men, 9 women: 63.1 ± 6.0 yr, 26.9 ± 4.2 kg·m-2, 8030 ± 3110 steps per day), 39 with T2D (23 men, 16 women: 61.2 ± 8.5 yr, 29.4 ± 6.4 kg·m-2, 8440 ± 4220 steps per day), and 27 controls (13 men, 14 women: 58.1 ± 9.4 yr, 27.3 ± 4.3 kg·m-2, 8400 ± 3000 steps per day) completed the Fatigue Impact Scale as a measure of perceived fatigability and a fatigue protocol including 120 maximal-effort, high-velocity concentric contractions (MVCC; 1 contraction/3 s) with the knee extensors using a submaximal load (30% maximum) to quantify performance fatigability. Electrical stimulation was used to assess voluntary activation and contractile function of the knee extensor muscles before and after the fatigue protocol. Results Fatigue Impact Scale scores were not different between people with prediabetes, people with T2D, and controls (12.5 ± 15.1, 18.3 ± 22.7, and 12.6 ± 18.6, respectively; P = 0.517). However, people with prediabetes had greater reductions in MVCC power during the fatigue protocol than did controls (31.8% ± 22.6% vs 22.1% ± 21.1%, P < 0.001), and both groups had lesser reductions than the T2D group (44.8% ± 21.9%, P < 0.001). Similarly, the prediabetes group had larger reductions in electrically evoked twitch amplitude than the control group (32.5% ± 24.9% vs 21.3% ± 33.0%, P < 0.001), but lesser reductions than those with T2D (44.0% ± 23.4%, P < 0.001). For all three groups, a greater decline in MVCC power was associated with larger reductions of twitch amplitude (r2 = 0.350, P < 0.001). Conclusion People with prediabetes have greater performance fatigability of the knee extensors due to contractile mechanisms compared with controls, although less performance fatigability than that of people with T2D.
AB - Introduction The study purpose was to compare perceived fatigability and performance fatigability after high-velocity contractions with knee extensor muscles between people with prediabetes, people with type 2 diabetes (T2D), and controls without diabetes matched for age, body mass index, and physical activity. Methods Twenty people with prediabetes (11 men, 9 women: 63.1 ± 6.0 yr, 26.9 ± 4.2 kg·m-2, 8030 ± 3110 steps per day), 39 with T2D (23 men, 16 women: 61.2 ± 8.5 yr, 29.4 ± 6.4 kg·m-2, 8440 ± 4220 steps per day), and 27 controls (13 men, 14 women: 58.1 ± 9.4 yr, 27.3 ± 4.3 kg·m-2, 8400 ± 3000 steps per day) completed the Fatigue Impact Scale as a measure of perceived fatigability and a fatigue protocol including 120 maximal-effort, high-velocity concentric contractions (MVCC; 1 contraction/3 s) with the knee extensors using a submaximal load (30% maximum) to quantify performance fatigability. Electrical stimulation was used to assess voluntary activation and contractile function of the knee extensor muscles before and after the fatigue protocol. Results Fatigue Impact Scale scores were not different between people with prediabetes, people with T2D, and controls (12.5 ± 15.1, 18.3 ± 22.7, and 12.6 ± 18.6, respectively; P = 0.517). However, people with prediabetes had greater reductions in MVCC power during the fatigue protocol than did controls (31.8% ± 22.6% vs 22.1% ± 21.1%, P < 0.001), and both groups had lesser reductions than the T2D group (44.8% ± 21.9%, P < 0.001). Similarly, the prediabetes group had larger reductions in electrically evoked twitch amplitude than the control group (32.5% ± 24.9% vs 21.3% ± 33.0%, P < 0.001), but lesser reductions than those with T2D (44.0% ± 23.4%, P < 0.001). For all three groups, a greater decline in MVCC power was associated with larger reductions of twitch amplitude (r2 = 0.350, P < 0.001). Conclusion People with prediabetes have greater performance fatigability of the knee extensors due to contractile mechanisms compared with controls, although less performance fatigability than that of people with T2D.
KW - DIABETES MELLITUS
KW - EXERCISE INTOLERANCE
KW - FATIGUE
KW - GLUCOSE INTOLERANCE
KW - KNEE EXTENSORS
KW - METABOLIC SYNDROME
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U2 - 10.1249/MSS.0000000000002238
DO - 10.1249/MSS.0000000000002238
M3 - Article
C2 - 31815831
AN - SCOPUS:85083906364
SN - 0195-9131
VL - 52
SP - 1176
EP - 1186
JO - Medicine and science in sports and exercise
JF - Medicine and science in sports and exercise
IS - 5
ER -