Abstract
This article reviews the mechanisms that lead to the development of Graves' ophthalmopathy. A central feature in its development is autoimmunity that involves not only T cells, B cells, and macrophages but also fibroblasts and adipose tissue within the orbit. Intraorbital cytokine-mediated inflammation also has a prominent role. These recent findings suggest new ways of treating this debilitating disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 726-738+774 |
| Journal | New England Journal of Medicine |
| Volume | 362 |
| Issue number | 8 |
| DOIs | |
| State | Published - Feb 25 2010 |
ASJC Scopus subject areas
- Medicine(all)