Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells

R. Bhattacharya; P. Mukherjee; Z. Xiong; A. Atala; S. Soker; D. Mukhopadhyay

doi:10.1021/nl0483789

Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells

R. Bhattacharya, P. Mukherjee, Z. Xiong, A. Atala, S. Soker, D. Mukhopadhyay

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

Gold nanoparticles inhibit VEGF165, a heparin binding growth factor, induced proliferation of HUVEC cells but do not interfere with the activity of VEGF121, a non-heparin binding growth factor. The interaction between gold nanoparticles and VEGF165 primarily occurs through the heparin binding domain of the protein. VEGF121 does not have a heparin binding domain and hence is not inactivated by gold nanoparticles.

Original language	English (US)
Pages (from-to)	2479-2481
Number of pages	3
Journal	Nano Letters
Volume	4
Issue number	12
DOIs	https://doi.org/10.1021/nl0483789
State	Published - Dec 2004

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl0483789

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title = "Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells",

abstract = "Gold nanoparticles inhibit VEGF165, a heparin binding growth factor, induced proliferation of HUVEC cells but do not interfere with the activity of VEGF121, a non-heparin binding growth factor. The interaction between gold nanoparticles and VEGF165 primarily occurs through the heparin binding domain of the protein. VEGF121 does not have a heparin binding domain and hence is not inactivated by gold nanoparticles.",

author = "R. Bhattacharya and P. Mukherjee and Z. Xiong and A. Atala and S. Soker and D. Mukhopadhyay",

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AU - Bhattacharya, R.

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AU - Atala, A.

AU - Soker, S.

AU - Mukhopadhyay, D.

PY - 2004/12

Y1 - 2004/12

N2 - Gold nanoparticles inhibit VEGF165, a heparin binding growth factor, induced proliferation of HUVEC cells but do not interfere with the activity of VEGF121, a non-heparin binding growth factor. The interaction between gold nanoparticles and VEGF165 primarily occurs through the heparin binding domain of the protein. VEGF121 does not have a heparin binding domain and hence is not inactivated by gold nanoparticles.

AB - Gold nanoparticles inhibit VEGF165, a heparin binding growth factor, induced proliferation of HUVEC cells but do not interfere with the activity of VEGF121, a non-heparin binding growth factor. The interaction between gold nanoparticles and VEGF165 primarily occurs through the heparin binding domain of the protein. VEGF121 does not have a heparin binding domain and hence is not inactivated by gold nanoparticles.

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Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells

Abstract

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