TY - JOUR
T1 - Global Longitudinal Strain as Predictor of Inducible Ischemia in No Obstructive Coronary Artery Disease in the CIAO-ISCHEMIA Study
AU - CIAO-ISCHEMIA Research Group
AU - Davis, Esther F.
AU - Crousillat, Daniela R.
AU - Peteiro, Jesus
AU - Lopez-Sendon, Jose
AU - Senior, Roxy
AU - Shapiro, Michael D.
AU - Pellikka, Patricia A.
AU - Lyubarova, Radmila
AU - Alfakih, Khaled
AU - Abdul-Nour, Khaled
AU - Anthopolos, Rebecca
AU - Xu, Yifan
AU - Kunichoff, Dennis M.
AU - Fleg, Jerome L.
AU - Spertus, John A.
AU - Hochman, Judith
AU - Maron, David
AU - Picard, Michael H.
AU - Reynolds, Harmony R.
N1 - Publisher Copyright:
© 2023 American Society of Echocardiography
PY - 2024/1
Y1 - 2024/1
N2 - Background: Global longitudinal strain (GLS) is a sensitive marker for identifying subclinical myocardial dysfunction in obstructive coronary artery disease (CAD). Little is known about the relationship between GLS and ischemia in patients with myocardial ischemia and no obstructive CAD (INOCA). Objectives: To investigate the relationship between resting GLS and ischemia on stress echocardiography (SE) in patients with INOCA. Methods: Left ventricular GLS was calculated offline on resting SE images at enrollment (n = 144) and 1-year follow-up (n = 120) in the CIAO-ISCHEMIA (Changes in Ischemia and Angina over One year in International Study of Comparative Health Effectiveness with Medical and Invasive Approaches trial screen failures with no obstructive CAD on computed tomography [CT] angiography) study, which enrolled participants with moderate or severe ischemia by local SE interpretation (≥3 segments with new or worsening wall motion abnormality and no obstructive (<50% stenosis) on coronary computed tomography angiography. Results: Global longitudinal strain values were normal in 83.3% at enrollment and 94.2% at follow-up. Global longitudinal strain values were not associated with a positive SE at enrollment (GLS = –21.5% positive SE vs GLS = –19.9% negative SE, P = .443) or follow-up (GLS = –23.2% positive SE vs GLS = –23.1% negative SE, P = .859). Significant change in GLS was not associated with positive SE in follow-up (P = .401). Regional strain was not associated with colocalizing ischemia at enrollment or follow-up. Changes in GLS and number of ischemic segments from enrollment to follow-up showed a modest but not clinically meaningful correlation (β = 0.41; 95% CI, 0.16, 0.67; P = .002). Conclusions: In this cohort of INOCA patients, resting GLS values were largely normal and did not associate with the presence, severity, or location of stress-induced ischemia. These findings may suggest the absence of subclinical myocardial dysfunction detectable by echocardiographic strain analysis at rest in INOCA.
AB - Background: Global longitudinal strain (GLS) is a sensitive marker for identifying subclinical myocardial dysfunction in obstructive coronary artery disease (CAD). Little is known about the relationship between GLS and ischemia in patients with myocardial ischemia and no obstructive CAD (INOCA). Objectives: To investigate the relationship between resting GLS and ischemia on stress echocardiography (SE) in patients with INOCA. Methods: Left ventricular GLS was calculated offline on resting SE images at enrollment (n = 144) and 1-year follow-up (n = 120) in the CIAO-ISCHEMIA (Changes in Ischemia and Angina over One year in International Study of Comparative Health Effectiveness with Medical and Invasive Approaches trial screen failures with no obstructive CAD on computed tomography [CT] angiography) study, which enrolled participants with moderate or severe ischemia by local SE interpretation (≥3 segments with new or worsening wall motion abnormality and no obstructive (<50% stenosis) on coronary computed tomography angiography. Results: Global longitudinal strain values were normal in 83.3% at enrollment and 94.2% at follow-up. Global longitudinal strain values were not associated with a positive SE at enrollment (GLS = –21.5% positive SE vs GLS = –19.9% negative SE, P = .443) or follow-up (GLS = –23.2% positive SE vs GLS = –23.1% negative SE, P = .859). Significant change in GLS was not associated with positive SE in follow-up (P = .401). Regional strain was not associated with colocalizing ischemia at enrollment or follow-up. Changes in GLS and number of ischemic segments from enrollment to follow-up showed a modest but not clinically meaningful correlation (β = 0.41; 95% CI, 0.16, 0.67; P = .002). Conclusions: In this cohort of INOCA patients, resting GLS values were largely normal and did not associate with the presence, severity, or location of stress-induced ischemia. These findings may suggest the absence of subclinical myocardial dysfunction detectable by echocardiographic strain analysis at rest in INOCA.
KW - Echocardiography
KW - INOCA
KW - Ischemia
KW - No obstructive disease
KW - Strain
KW - Stress testing
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U2 - 10.1016/j.echo.2023.09.006
DO - 10.1016/j.echo.2023.09.006
M3 - Article
C2 - 37722490
AN - SCOPUS:85176112102
SN - 0894-7317
VL - 37
SP - 89
EP - 99
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 1
ER -