Glioblastoma as an age-related neurological disorder in adults

Miri Kim, Erik Ladomersky, Andreas Mozny, Masha Kocherginsky, Kaitlyn O'shea, Zachary Z. Reinstein, Lijie Zhai, April Bell, Kristen L. Lauing, Lakshmi Bollu, Erik Rabin, Karan Dixit, Priya Kumthekar, Leonidas C. Platanias, Lifang Hou, Yinan Zheng, Jennifer Wu, Bin Zhang, Maya Hrachova, Sarah A. MerrillMaciej M. Mrugala, Vikram C. Prabhu, Craig Horbinski, Charles David James, Bakhtiar Yamini, Quinn T. Ostrom, Margaret O. Johnson, David A. Reardon, Rimas V. Lukas, Derek A. Wainwright

Research output: Contribution to journalArticlepeer-review


Background: Advanced age is a major risk factor for the development of many diseases including those affecting the central nervous system. Wild-type isocitrate dehydrogenase glioblastoma (IDHwt GBM) is the most common primary malignant brain cancer and accounts for ≥90% of all adult GBM diagnoses. Patients with IDHwt GBM have a median age of diagnosis at 68-70 years of age, and increasing age is associated with an increasingly worse prognosis for patients with this type of GBM. Methods: The Surveillance, Epidemiology, and End Results, The Cancer Genome Atlas, and the Chinese Glioma Genome Atlas databases were analyzed for mortality indices. Meta-analysis of 80 clinical trials was evaluated for log hazard ratio for aging to tumor survivorship. Results: Despite significant advances in the understanding of intratumoral genetic alterations, molecular characteristics of tumor microenvironments, and relationships between tumor molecular characteristics and the use of targeted therapeutics, life expectancy for older adults with GBM has yet to improve. Conclusions: Based upon the results of our analysis, we propose that age-dependent factors that are yet to be fully elucidated, contribute to IDHwt GBM patient outcomes.

Original languageEnglish (US)
Article numbervdab125
JournalNeuro-Oncology Advances
Issue number1
StatePublished - Jan 1 2021


  • CD4
  • IDO
  • aging
  • glioma
  • immunotherapy
  • senescence

ASJC Scopus subject areas

  • Clinical Neurology
  • Oncology
  • Surgery


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