Ginseng radix increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes

Baek Vin Lim; Min Chul Shin; Mi Hyeon Jang; Taeck Hyun Lee; Young Pyo Kim; Hyun Bae Kim; Kwang Sik Lee; Hong Kim; Ee Hwa Kim; Chang Ju Kim

doi:10.1248/bpb.25.1550

Ginseng radix increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes

Baek Vin Lim, Min Chul Shin, Mi Hyeon Jang, Taeck Hyun Lee, Young Pyo Kim, Hyun Bae Kim, Kwang Sik Lee, Hong Kim, Ee Hwa Kim, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

In the present study, the effect of Ginseng radix on cell proliferation in the dentate gyrus of rats with streptozotocin-induced diabetes was investigated via immunohistochemistry. Aqueous extract of Ginseng radix was shown to exert no significant effect on weight in normal rats, while it prevented weight loss in rats with streptozotocin-induced diabetes. Cell proliferation in the dentate gyrus of diabetic rats was increased by Ginseng radix treatment, but it had no effect on cell proliferation in normal rats. These results suggest that Ginseng radix may help in improve the central nervous system complications of diabetes mellitus.

Original language	English (US)
Pages (from-to)	1550-1554
Number of pages	5
Journal	Biological and Pharmaceutical Bulletin
Volume	25
Issue number	12
DOIs	https://doi.org/10.1248/bpb.25.1550
State	Published - Dec 2002

Keywords

Cell proliferation
Dentate gyrus
Ginseng radix, streptozotocin-induced diabetes

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1248/bpb.25.1550

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abstract = "In the present study, the effect of Ginseng radix on cell proliferation in the dentate gyrus of rats with streptozotocin-induced diabetes was investigated via immunohistochemistry. Aqueous extract of Ginseng radix was shown to exert no significant effect on weight in normal rats, while it prevented weight loss in rats with streptozotocin-induced diabetes. Cell proliferation in the dentate gyrus of diabetic rats was increased by Ginseng radix treatment, but it had no effect on cell proliferation in normal rats. These results suggest that Ginseng radix may help in improve the central nervous system complications of diabetes mellitus.",

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AU - Lim, Baek Vin

AU - Shin, Min Chul

AU - Jang, Mi Hyeon

AU - Lee, Taeck Hyun

AU - Kim, Young Pyo

AU - Kim, Hyun Bae

AU - Lee, Kwang Sik

AU - Kim, Hong

AU - Kim, Ee Hwa

AU - Kim, Chang Ju

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Ginseng radix increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes

Abstract

Keywords

ASJC Scopus subject areas

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