Giant cell myocarditis as a manifestation of drug hypersensitivity

Paul R. Daniels, Gerald J. Berry, Henry D. Tazelaar, Leslie T. Cooper

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Adverse drug effects on the myocardium are often classified into toxic and hypersensitivity forms of myocarditis, each with distinct histologic findings. In contrast, giant cell myocarditis (GCM) is generally not associated with adverse drug reactions and has unique histopathologic features. We report four cases of adverse drug reactions in which the histologic findings were characteristic of GCM. The clinical recognition that GCM may be a manifestation of an adverse drug reaction is important, since the prognosis and treatment of this entity may be different from that of other forms of myocarditis. (C) 2000 by Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalCardiovascular Pathology
Issue number5
StatePublished - 2000

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cardiology and Cardiovascular Medicine


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