Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon

William A. Hammond, Jennifer A. Crozier, Raouf E. Nakhleh, Kabir Mody

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


High-grade neuroendocrine carcinoma (HGNEC) of the colon is a rare and aggressive cancer that has a poor prognosis. Currently no standard treatment exists, and published case series report an overall survival of approximately one year with treatment. Typically patients receive treatment similar to that recommended for small-cell lung cancer, extrapolating from the similarity in cancer biology. Here we report a case of HGNEC of the colon with genomic profiling that identified a KRAS G12D mutation and a PI3K mutation that has not yet been reported in the literature for this tumor type.

Original languageEnglish (US)
Pages (from-to)E22-E24
JournalJournal of Gastrointestinal Oncology
Issue number2
StatePublished - Apr 1 2016


  • Colon cancer
  • Genomic profiling
  • Neuroendocrine carcinoma

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology


Dive into the research topics of 'Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon'. Together they form a unique fingerprint.

Cite this