@inbook{d6375de4c71546afbe60ba96005c4727,
title = "Genetics in clinical trials",
abstract = "Pharmacogenetics is founded on longstanding traditions in clinical practice, where therapies are selected based on history and physical findings in order to maximize benefit and minimize risk. Genetic tools allow increased sophistication in patient profiling and treatment optimization. Pharmaceutical companies are aware of the value of collecting genetic data during their clinical trials [17, 18]. Pharmacogenetics research is bidirectional with clinical trials: efficacy data are correlated with genetic polymorphisms, which in turn define subjects for treatment stratification. Currently, pharmacogenetics is in its infancy. Nonetheless, we anticipate that the identification of disease-specific genes will result in earlier diagnostic measures, disease progression markers and targets for therapeutic discovery.",
author = "Meschia, {James F.} and Katrina Gwinn",
year = "2009",
doi = "10.1159/000209494",
language = "English (US)",
isbn = "9783805590235",
series = "Frontiers of Neurology and Neuroscience",
pages = "152--157",
booktitle = "Clinical Trials in the Neurosciences",
}