Abstract
Antiepileptic mood stabilizers (AED-MS) are often used to treat bipolar disorder (BD). Similar to other mood disorder medications, AED-MS treatment response varies between patients. Identification of biomarkers associated with treatment response may ultimately help with the delivery of individualized treatment and lead to improved treatment efficacy. Here, we conducted a narrative review of the current knowledge of the pharmacogenomics of AED-MS (valproic acid, lamotrigine and carbamazepine) treatment response in BD, including genetic contributions to AED-MS pharmacokinetics. Genes involved in neurotransmitter systems and drug transport have been shown to be associated with AED-MS treatment response. As more studies are conducted, and experimental and analytical methods advance, knowledge of AED-MS pharmacogenomics is expected to grow and contribute to precision medicine in BD.
Original language | English (US) |
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Pages (from-to) | 913-925 |
Number of pages | 13 |
Journal | Pharmacogenomics |
Volume | 22 |
Issue number | 14 |
DOIs | |
State | Published - Sep 2021 |
Keywords
- anticonvulsants
- antiepileptics
- bipolar disorder
- mood stabilizers
- pharmacogenomics
- treatment response
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Pharmacology