Genetic testing for young-onset colorectal cancer: Case report and evidence-based clinical guidelines

Yaolin Zhou, Lisa Boardman, Robert Miller

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background. Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis. Case report. We describe the case of a 44-year-old man with a paternal history of colon polyps, a personal 2-year history of hematochezia, and a diagnosis of rectal cancer. Further clinical evaluation of the patient at our institution determined the cancer to be stage IIIA. The patient underwent genetic counseling and testing, which indicated he was negative for the most common familial cancer syndromes. After treatment with neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy, the patient has done well. We review the hereditary cancer syndromes and genetic tests to consider for patients with early-onset colorectal cancer. Conclusions. This case underscores the importance of following cancer-screening guidelines.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalRadiology and Oncology
Issue number1
StatePublished - Mar 1 2010


  • Adenomatous polyposis coli
  • Attenuated familial adenomatous polyposis
  • Colorectal cancer
  • Familial adenomatous polyposis
  • MYH-associated polyposis
  • Microsatellite instability

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Genetic testing for young-onset colorectal cancer: Case report and evidence-based clinical guidelines'. Together they form a unique fingerprint.

Cite this