Genetic risk identifies multiple myeloma patients who do not benefit from autologous stem cell transplantation

Hong Chang; X. Y. Qi; S. Samiee; Q. L. Yi; C. Chen; S. Trudel; J. Mikhael; D. Reece; A. K. Stewart

doi:10.1038/sj.bmt.1705131

Genetic risk identifies multiple myeloma patients who do not benefit from autologous stem cell transplantation

Hong Chang, X. Y. Qi, S. Samiee, Q. L. Yi, C. Chen, S. Trudel, J. Mikhael, D. Reece, A. K. Stewart

Hematology/Oncology

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Genetic aberrations have emerged as major prognostic factors for patients with multiple myeloma (MM). We evaluated 126 MM patients for t(4;14) or t(11;14), 13q or p53 deletions and correlated the number of genetic aberrations with patient's clinical outcome following undergoing autologous stem cell transplantation. We demonstrate the significance of genetic-based risk classification that clearly segregate patients into low (no genetic abnormalities or only t(11;14)), intermediate (any one of the genetic abnormalities other than t(11;14)) and high-risk groups (any two or more of the genetic abnormalities other than t(11;14)). High-risk patients do not benefit from stem cell transplant and should be offered alternative therapies.

Original language	English (US)
Pages (from-to)	793-796
Number of pages	4
Journal	Bone Marrow Transplantation
Volume	36
Issue number	9
DOIs	https://doi.org/10.1038/sj.bmt.1705131
State	Published - Nov 2005

Keywords

13q deletions
Autologous stem cell transplantation
Fluorescence in situ hybridization
IgH translocations
Multiple myeloma
p53 deletions

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1705131

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@article{336286dda22d4703aa56045e0f884ee0,

title = "Genetic risk identifies multiple myeloma patients who do not benefit from autologous stem cell transplantation",

abstract = "Genetic aberrations have emerged as major prognostic factors for patients with multiple myeloma (MM). We evaluated 126 MM patients for t(4;14) or t(11;14), 13q or p53 deletions and correlated the number of genetic aberrations with patient's clinical outcome following undergoing autologous stem cell transplantation. We demonstrate the significance of genetic-based risk classification that clearly segregate patients into low (no genetic abnormalities or only t(11;14)), intermediate (any one of the genetic abnormalities other than t(11;14)) and high-risk groups (any two or more of the genetic abnormalities other than t(11;14)). High-risk patients do not benefit from stem cell transplant and should be offered alternative therapies.",

keywords = "13q deletions, Autologous stem cell transplantation, Fluorescence in situ hybridization, IgH translocations, Multiple myeloma, p53 deletions",

author = "Hong Chang and Qi, {X. Y.} and S. Samiee and Yi, {Q. L.} and C. Chen and S. Trudel and J. Mikhael and D. Reece and Stewart, {A. K.}",

note = "Funding Information: This study was supported in part by a grant from the Leukemia Research Fund of Canada, Canadian Institute for Health Research and National Cancer Institute of Canada.",

year = "2005",

month = nov,

doi = "10.1038/sj.bmt.1705131",

language = "English (US)",

volume = "36",

pages = "793--796",

journal = "Bone Marrow Transplantation",

issn = "0268-3369",

publisher = "Nature Publishing Group",

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T1 - Genetic risk identifies multiple myeloma patients who do not benefit from autologous stem cell transplantation

AU - Chang, Hong

AU - Qi, X. Y.

AU - Samiee, S.

AU - Yi, Q. L.

AU - Chen, C.

AU - Trudel, S.

AU - Mikhael, J.

AU - Reece, D.

AU - Stewart, A. K.

N1 - Funding Information: This study was supported in part by a grant from the Leukemia Research Fund of Canada, Canadian Institute for Health Research and National Cancer Institute of Canada.

PY - 2005/11

Y1 - 2005/11

N2 - Genetic aberrations have emerged as major prognostic factors for patients with multiple myeloma (MM). We evaluated 126 MM patients for t(4;14) or t(11;14), 13q or p53 deletions and correlated the number of genetic aberrations with patient's clinical outcome following undergoing autologous stem cell transplantation. We demonstrate the significance of genetic-based risk classification that clearly segregate patients into low (no genetic abnormalities or only t(11;14)), intermediate (any one of the genetic abnormalities other than t(11;14)) and high-risk groups (any two or more of the genetic abnormalities other than t(11;14)). High-risk patients do not benefit from stem cell transplant and should be offered alternative therapies.

AB - Genetic aberrations have emerged as major prognostic factors for patients with multiple myeloma (MM). We evaluated 126 MM patients for t(4;14) or t(11;14), 13q or p53 deletions and correlated the number of genetic aberrations with patient's clinical outcome following undergoing autologous stem cell transplantation. We demonstrate the significance of genetic-based risk classification that clearly segregate patients into low (no genetic abnormalities or only t(11;14)), intermediate (any one of the genetic abnormalities other than t(11;14)) and high-risk groups (any two or more of the genetic abnormalities other than t(11;14)). High-risk patients do not benefit from stem cell transplant and should be offered alternative therapies.

KW - 13q deletions

KW - Autologous stem cell transplantation

KW - Fluorescence in situ hybridization

KW - IgH translocations

KW - Multiple myeloma

KW - p53 deletions

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Genetic risk identifies multiple myeloma patients who do not benefit from autologous stem cell transplantation

Abstract

Keywords

ASJC Scopus subject areas

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