Genetic polymorphisms in southwest alaskan eskimos

Gloria M. Petersen, Joel I. Ward, Paul I. Terasaki, Moses S. Schanfiel, Robert E. Ferrell, Edward M. Scott, Min S. Park

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Allele frequencies of 28 genelic loci were determined in subsets (n ranged from 52 to 698) of a sample of Yupik-speaking Eskimos from southwestern Alaska. Five loci were monomorphic (KellKp(b+), ADA1, AK1, HBA, and PGDA). At the other loci, the most frequent alleles were ABO0 (0.580), Fya (0.960), Jkb (0.513), Ms (0.333), CDe (0.591), ACPA (0.566), ESD1 (0.890), GLO2 (0.736), GPT1, (0.653), Hp2 (0.654), PGM1, (0.836), PGP1, (0.972), and UMPK1 (0.873). The most frequent immunoglobulin allotypeGm(l;21) occurred with a frequency of 0.829. The HLA alleles that occurred with highest frequencies were A24 (0.626), Bw48 (0.184), Cw3 (0.404), and DR4 (0.329). The average heterozygosity at all loci was 0.423. Based on the presence of the European allotype, Gm3;23;5, 11, 13the proportion of European admixture in the Eskimo population was estimated to be 2.1%.

Original languageEnglish (US)
Pages (from-to)236-247
Number of pages12
JournalHuman Heredity
Issue number4
StatePublished - 1991


  • Admixture
  • Eskimo
  • Genetic polymorphisms
  • Human lymphocyte antigens
  • Immunoglobulins

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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