TY - JOUR
T1 - Genetic polymorphisms in southwest alaskan eskimos
AU - Petersen, Gloria M.
AU - Ward, Joel I.
AU - Terasaki, Paul I.
AU - Schanfiel, Moses S.
AU - Ferrell, Robert E.
AU - Scott, Edward M.
AU - Park, Min S.
PY - 1991
Y1 - 1991
N2 - Allele frequencies of 28 genelic loci were determined in subsets (n ranged from 52 to 698) of a sample of Yupik-speaking Eskimos from southwestern Alaska. Five loci were monomorphic (KellKp(b+), ADA1, AK1, HBA, and PGDA). At the other loci, the most frequent alleles were ABO0 (0.580), Fya (0.960), Jkb (0.513), Ms (0.333), CDe (0.591), ACPA (0.566), ESD1 (0.890), GLO2 (0.736), GPT1, (0.653), Hp2 (0.654), PGM1, (0.836), PGP1, (0.972), and UMPK1 (0.873). The most frequent immunoglobulin allotypeGm(l;21) occurred with a frequency of 0.829. The HLA alleles that occurred with highest frequencies were A24 (0.626), Bw48 (0.184), Cw3 (0.404), and DR4 (0.329). The average heterozygosity at all loci was 0.423. Based on the presence of the European allotype, Gm3;23;5, 11, 13the proportion of European admixture in the Eskimo population was estimated to be 2.1%.
AB - Allele frequencies of 28 genelic loci were determined in subsets (n ranged from 52 to 698) of a sample of Yupik-speaking Eskimos from southwestern Alaska. Five loci were monomorphic (KellKp(b+), ADA1, AK1, HBA, and PGDA). At the other loci, the most frequent alleles were ABO0 (0.580), Fya (0.960), Jkb (0.513), Ms (0.333), CDe (0.591), ACPA (0.566), ESD1 (0.890), GLO2 (0.736), GPT1, (0.653), Hp2 (0.654), PGM1, (0.836), PGP1, (0.972), and UMPK1 (0.873). The most frequent immunoglobulin allotypeGm(l;21) occurred with a frequency of 0.829. The HLA alleles that occurred with highest frequencies were A24 (0.626), Bw48 (0.184), Cw3 (0.404), and DR4 (0.329). The average heterozygosity at all loci was 0.423. Based on the presence of the European allotype, Gm3;23;5, 11, 13the proportion of European admixture in the Eskimo population was estimated to be 2.1%.
KW - Admixture
KW - Eskimo
KW - Genetic polymorphisms
KW - Human lymphocyte antigens
KW - Immunoglobulins
UR - http://www.scopus.com/inward/record.url?scp=0026044736&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026044736&partnerID=8YFLogxK
U2 - 10.1159/000154008
DO - 10.1159/000154008
M3 - Article
C2 - 1783412
AN - SCOPUS:0026044736
SN - 0001-5652
VL - 41
SP - 236
EP - 247
JO - Human Heredity
JF - Human Heredity
IS - 4
ER -