Genetic events in the pathogenesis of multiple myeloma

W. J. Chng, O. Glebov, P. L. Bergsagel, W. M. Kuehl

Research output: Contribution to journalReview articlepeer-review

149 Scopus citations


The genetics of myeloma has been increasingly elucidated in recent years. Recurrent genetic events, and also biologically distinct and clinically relevant genetic subtypes of myeloma have been defined. This has facilitated our understanding of the molecular pathogenesis of the disease. In addition, some genetic abnormalities have proved to be highly reproducible prognostic factors. With the expanding therapeutic armamentarium, it is time to include genetic assessment as part of clinical evaluation of myeloma patients to guide management. In this review we examine the role of various genetic abnormalities in the molecular pathogenesis of myeloma, and the use of such abnormalities in disease classification, prognosis and clinical management.

Original languageEnglish (US)
Pages (from-to)571-596
Number of pages26
JournalBest Practice and Research: Clinical Haematology
Issue number4
StatePublished - Dec 2007


  • IgH translocations
  • gene expression profiling
  • genetics
  • hyperdiploid
  • molecular pathogenesis
  • prognosis

ASJC Scopus subject areas

  • Oncology
  • Clinical Biochemistry


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