Genetic counseling in hereditary nonpolyposis colorectal cancer: An extended family with MSH2 mutation

Henry T. Lynch, Stephen Lemon, Thomas Smyrk, Barbara Franklin, Beth Karr, Jane Lynch, Susan Slominski-Caster, Patricia Murphy, Christopher Connolly

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objectives: Molecular genetic advances have increased the demand for DNA testing. We describe DNA based genetic counseling in a hereditary nonpolyposis colorectal cancer (HNPCC) family. Methods: This extended HNPCC family was found to harbor the MSH2 germline mutation. Family history, medical, and pathology documents enabled us to secure a high degree of verification that the kindred qualified as HNPCC. DNA testing revealed the MSH2 germline mutation that was verified independently in two laboratories. Genetic counseling was provided before DNA testing and disclosure of MSH2 findings. Results: Genetic counseling revealed a variety of findings characterized by emotional stress in MSH2 germline mutation carriers. Concerns centered around reproductive issues, potential transmission of the deleterious gene to their progeny, and discrimination by insurance carriers and employers. More than one-half of the patients found to harbor the MSH2 mutation considered the option of prophylactic subtotal colectomy. Conclusion: DNA testing should be restricted to well-verified candidate families in which genetic counseling should be mandatory. HNPCC family members sought genetic risk assessment for their own health and that of their children. Contrasting emotional responses took place when told of their gene testing status and this required a sensitive empathetic listening ear. Patients have many concerns about their lifetime cancer destiny when told that they harbor the culprit MSH2 germline mutation.

Original languageEnglish (US)
Pages (from-to)2489-2493
Number of pages5
JournalAmerican Journal of Gastroenterology
Issue number12
StatePublished - Dec 1996

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Genetic counseling in hereditary nonpolyposis colorectal cancer: An extended family with MSH2 mutation'. Together they form a unique fingerprint.

Cite this