Genetic causes of stroke

Research output: Chapter in Book/Report/Conference proceedingChapter


Studies of twins and other family structures have generally shown a tendency for stroke to cluster within families. Defining the molecular basis for the inherited risk of so-called common stroke is a work in progress. Although the genetics of common stroke are reviewed, this chapter focuses mainly on known mendelian and mitochondrial disorders that cause ischemic stroke, hemorrhagic stroke, and cerebrovascular malformations. Some genetic disorders, such as sickle cell anemia and Fabry disease, have proven therapies, whereas others have no effective treatment. However, it remains essential for physicians to diagnose even presently untreatable familial disorders. Early diagnosis of such genetic disorders spares patients from needless and potentially dangerous diagnostic tests and ineffective therapies. A precise diagnosis of a genetic disorder also permits rational family counseling. II. IMPORTANCE OF A DETAILED FAMILY HISTORY.

Original languageEnglish (US)
Title of host publicationHandbook of Cerebrovascular Diseases, Second Edition, Revised and Expanded
PublisherCRC Press
Number of pages19
ISBN (Electronic)9780203996942
ISBN (Print)9780824753900
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Genetic causes of stroke'. Together they form a unique fingerprint.

Cite this