TY - JOUR
T1 - Genetic Approaches for Sports Performance
T2 - How Far Away Are We?
AU - Joyner, Michael J.
N1 - Funding Information:
This supplement is supported by the Gatorade Sports Science Institute (GSSI). The supplement was guest edited by Lawrence L. Spriet, who attended a meeting of the GSSI Expert Panel in March 2019 and received honoraria from the GSSI, a division of PepsiCo, Inc., for his participation in the meeting. Dr. Spriet received no honorarium for guest editing the supplement. Dr. Spriet suggested peer reviewers for each paper, which were sent to the Sports Medicine Editor-in-Chief for approval, prior to any reviewers being approached. Dr. Spriet provided comments on each paper and made an editorial decision based on comments from the peer reviewers and the Editor-in-Chief. Where decisions were uncertain, Dr. Spriet consulted with the Editor-in-Chief.
Funding Information:
This supplement is supported by the Gatorade Sports Science Institute (GSSI). The supplement was guest edited by Lawrence L. Spriet, who attended a meeting of the GSSI Expert Panel in March 2019 and received honoraria from the GSSI, a division of PepsiCo, Inc., for his participation in the meeting. Dr. Spriet received no honorarium for guest editing the supplement. Dr. Spriet suggested peer reviewers for each paper, which were sent to the Sports Medicine Editor-in-Chief for approval, prior to any reviewers being approached. Dr. Spriet provided comments on each paper and made an editorial decision based on comments from the peer reviewers and the Editor-in-Chief. Where decisions were uncertain, Dr. Spriet consulted with the Editor-in-Chief.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Humans vary in their ‘natural ability’ related to sports performance. One facet of natural ability reflects so-called intrinsic ability or the ability to do well with minimal training. A second facet of natural ability is how rapidly an individual adapts to training; this is termed trainability. A third facet is the upper limit achievable after years of prolonged intense training; this represents both intrinsic ability and also trainability. There are other features of natural ability to consider, for example body size, because some events, sports, or positions favor participants of different sizes. In this context, the physiological determinants of elite endurance performance, especially running and cycling, are well known and can be used as a template to discuss these general issues. The key determinants of endurance performance include maximal oxygen uptake (V˙ O 2 max) , the lactate threshold, and running economy (efficiency in the case of cycling or other sports). In this article, I use these physiological determinants to explore what is known about the genetics of endurance performance. My main conclusion is that at this time there are very few, if any, obvious relationships between these key physiological determinants of performance and DNA sequence variation. Several potential reasons for this lack of relationship will be discussed.
AB - Humans vary in their ‘natural ability’ related to sports performance. One facet of natural ability reflects so-called intrinsic ability or the ability to do well with minimal training. A second facet of natural ability is how rapidly an individual adapts to training; this is termed trainability. A third facet is the upper limit achievable after years of prolonged intense training; this represents both intrinsic ability and also trainability. There are other features of natural ability to consider, for example body size, because some events, sports, or positions favor participants of different sizes. In this context, the physiological determinants of elite endurance performance, especially running and cycling, are well known and can be used as a template to discuss these general issues. The key determinants of endurance performance include maximal oxygen uptake (V˙ O 2 max) , the lactate threshold, and running economy (efficiency in the case of cycling or other sports). In this article, I use these physiological determinants to explore what is known about the genetics of endurance performance. My main conclusion is that at this time there are very few, if any, obvious relationships between these key physiological determinants of performance and DNA sequence variation. Several potential reasons for this lack of relationship will be discussed.
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U2 - 10.1007/s40279-019-01164-z
DO - 10.1007/s40279-019-01164-z
M3 - Review article
C2 - 31691930
AN - SCOPUS:85074899603
SN - 0112-1642
VL - 49
SP - 199
EP - 204
JO - Sports Medicine
JF - Sports Medicine
ER -