General approaches to measuring immune responses

Mary L. Disis, Keith L. Knutson

Research output: Chapter in Book/Report/Conference proceedingChapter


Our understanding of the T cell immune response directed against tumors has advanced significantly over the past several years. As a result, a host of immune-based strategies for treating and preventing cancer are being tested in the clinic. The development of reproducible and quantitative methods for monitoring tumor-specific immunity has also become better defined. Assays, such as ELISPOT and MHC tetramers, that a few years ago were used only by a very few investigators, have now become standard tools for tumor immunologists. Standard quantitative methods are undergoing a reevaluation as newer approaches are developed which focus on potential functions of the induced immune response. In the future, assessment of the tumor-specific immune response will entail a combination of assays directed against both measuring the direct effect of the immune manipulation as well as methods that assess the effect of such interventions on the immune microenvironment.

Original languageEnglish (US)
Title of host publicationGeneral Principles of Tumor Immunotherapy
Subtitle of host publicationBasic and Clinical Applications of Tumor Immunology
PublisherSpringer Netherlands
Number of pages12
ISBN (Electronic)9781402060878
ISBN (Print)9781402060861
StatePublished - 2008

ASJC Scopus subject areas

  • General Medicine


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