Gene therapy for rheumatoid arthritis

Elvire Gouze, Steven C. Ghivizzani, Paul D. Robbins, Christopher H. Evans

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Rheumatoid arthritis (RA) is a painful chronic disorder. Conventional therapies are palliative, not curative. Advances in the understanding of the pathophysiology of RA have led to the development of new therapeutic strategies, including gene therapy. Multiple studies in several different animal models provide proof supporting the use of gene therapy in arthritis. A phase I clinical trial has already been performed successfully on nine women with end-stage RA in the United States, and two other trials are in progress. Limited duration of gene expression impedes the development of a clinically useful genetic treatment for arthritis.

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalCurrent rheumatology reports
Issue number1
StatePublished - Feb 2001


  • Arthritic Joint
  • Gene Therapy
  • Human Synovial Fibroblast
  • Rheumatoid Arthritis
  • Rheumatoid Arthritis Synoviocytes

ASJC Scopus subject areas

  • Rheumatology


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