Application des techniques de thérapie génique aux maladies ostéo-articulaires

Translated title of the contribution: Gene therapy for osteoarticular disorders

Jean Noël Gouze, Christopher H. Evans, Steven C. Ghivizzani, Elvire Gouze

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Osteoarticular disorders are the major cause of disability in Europe and North America. It is estimated that rheumatoid arthritis affects 1 % of the population and that more than two third of people over age 55 develop osteoarthritis. Because there are no satisfactory treatments, gene therapy offers a new therapeutic approach. The delivery of cDNA encoding anti-arthritic proteins to articular cells has shown therapeutic efficacy in numerous animal models in vivo. Through the development and the experimental progresses that have been made for both rheumatoid arthritis and osteoarthritis, this review discusses the different gene therapy strategies available today and the safety issues with which they may be associated. Among the different vectors available today, adeno-associated virus seems the best candidate for a direct in vivo gene delivery approach for the treatment of joint disorders.

Translated title of the contributionGene therapy for osteoarticular disorders
Original languageFrench
Pages (from-to)303-309
Number of pages7
Issue number3
StatePublished - Mar 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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