Gene therapy approaches for multiple myeloma

Stephen J. Russell, Cynthia E. Dunbar

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Several different myeloma gene therapy approaches are currently being explored, seeking to impact on the disease process in diverse ways. Therapeutic benefit may result from destroying the myeloma cells directly, provoking an antimyeloma cell immune response, interfering with the paracrine growth signaling pathways between osteoclasts and myeloma cells, or genetically manipulating hematopoletic progenitors or mature T cells in a stem cell transplantation setting. Encouraging progress in each of these areas is being fueled by the development of improved viral and nonviral gene transfer vectors.

Original languageEnglish (US)
Pages (from-to)268-275
Number of pages8
JournalSeminars in Hematology
Issue number3
StatePublished - 2001

ASJC Scopus subject areas

  • Hematology


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